Sleep homeostasis: Progress at a snail’s pace

Evolution at a different pace: distinctive phylogenetic patterns of cone snails from two ancient oceanic archipelagos.

Ancient oceanic archipelagos of similar geological age are expected to accrue comparable numbers of endemic lineages with identical life history strategies, especially if the islands exhibit analogous habitats. We tested this hypothesis using marine snails of the genus Conus from the Atlantic archipelagos of Cape Verde and Canary Islands. Together with Azores and Madeira, these archipelagos com...

Targeted therapy: the fast pace of progress.

Circulation: cardiovascular interventions: keeping pace with progress.

Welcome to the first issue of Circulation: Cardiovascular Interventions, the fourth of 6 new journals to join the AHA family. The AHA Scientific Publishing Committee made the decision to expand the AHA journals because it recognized that to fulfill its mission to widely and effectively disseminate scientific information, it should more effectively address the needs of the subspecialty areas in ...

Sleep and synaptic homeostasis.

In the last decades a substantial knowledge about sleep mechanisms has been accumulated. However, the function of sleep still remains elusive. The difficulty with unraveling sleep's function may arise from the lack of understanding of how the multitude of processes associated with waking and sleep-from gene expression and single neuron activity to the whole brain dynamics and behavior-functiona...

Spindle assembly at a BRISC pace

Yan et al. describe how a deubiquitinating enzyme complex regulates the mitotic spindle assembly factor NuMA. BRCC36 is a de-ubiquitinating enzyme that preferentially cleaves lysine 63–linked poly-ubiquitin chains. As part of the Rap80 complex, BRCC36 regulates the repair of DNA double-strand breaks, but the enzyme can also assemble into a distinct complex, known as BRISC. Yan et al. found that...